Status:
RECRUITING
Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection
Lead Sponsor:
Mount Sinai Hospital, Canada
Collaborating Sponsors:
Sault Area Hospital
Michael Garron Hospital
Conditions:
Infectious Disease
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Delirium is an acute confusional state that is experienced by many older adults who are admitted to hospital. To treat delirium the underlying cause needs to be identified promptly, but this is challe...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Age ≥ 60 and admitted to a hospital ward (including rehabilitation hospital);
- Active delirium (defined by CAM: \[1\] inattention AND \[2\] acute and fluctuating level of consciousness, and either \[3\] disorganized thinking OR \[4\] altered mental status; OR physician's diagnosis)
- Less than 24 hours of antibiotics (prior to trial assessment)
- Either pyuria (defined as white blood cells detected on urinalysis or dipstick) or bacteriuria (defined as bacteria growing on urine culture)
- Exclusion criteria
- Fever (temperature \> 37.9C or \> 100.2F) in the past 48 hours;
- Signs of lower urinary tract infection symptoms (such as new dysuria) or upper urinary symptoms (such as costovertebral tenderness)
- In the opinion of the treating physician, there is a reason apart from delirium and urine test results to treat with antibiotics (e.g., pneumonia)
- Indwelling urinary catheter for \> 72 hours
- Receipt of an antibiotic where a single dose suffices for the treatment of a UTI (such as Fosfomycin)
Exclusion
Key Trial Info
Start Date :
May 18 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
550 Patients enrolled
Trial Details
Trial ID
NCT06004739
Start Date
May 18 2024
End Date
September 1 2027
Last Update
September 19 2024
Active Locations (7)
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1
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
2
The Ottawa Hospital Civic Campus
Ottawa, Canada
3
The Ottawa Hospital General Campus
Ottawa, Canada
4
Hennick Bridgepoint Hospital
Toronto, Canada