Status:
TERMINATED
Multiple Ascending-Dose Study of XmAb®27564 in Patients With Psoriasis or Atopic Dermatitis
Lead Sponsor:
Xencor, Inc.
Conditions:
Psoriasis
Atopic Dermatitis
Eligibility:
All Genders
18-75 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to evaluate the safety and tolerability of XmAb27564 following multiple doses among participants with plaque psoriasis and atopic dermatitis.
Detailed Description
This is a phase 1b, randomized, double-blind, placebo-controlled, multiple ascending dose (MAD) study of XmAb27564. It is planned to enroll approximately 48 adult patients with mild-to-severe plaque p...
Eligibility Criteria
Inclusion
- The main inclusion and exclusion criteria include, but are not limited to, the following:
- Have active mild-to-severe plaque psoriasis or moderate-to-severe atopic dermatitis according to study-specific criteria
- Weight between 40 to 150 kg, inclusive
- No topical treatments for psoriasis or atopic dermatitis for 2 weeks before randomization
- No phototherapy for psoriasis for 4 weeks before randomization
- Washout of oral treatments for psoriasis or atopic dermatitis for 4 weeks before randomization
- Washout of biologic treatments for psoriasis or atopic dermatitis for 12 weeks before randomization
- Stated willingness to comply with all study procedures (including skin biopsies) and availability for the duration of the study
Exclusion
- Patients with a history of active asthma within 5 years of screening, except those that have well controlled asthma symptoms at screening visit.
- Patients who have had any prior investigational treatment with IL-2 therapies
Key Trial Info
Start Date :
October 10 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 22 2024
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT06005792
Start Date
October 10 2022
End Date
November 22 2024
Last Update
December 2 2025
Active Locations (7)
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1
Unison Clinical Trials
Sherman Oaks, California, United States, 91403
2
Clinical Trials Research Institute
Thousand Oaks, California, United States, 91320
3
Driven Research
Coral Gables, Florida, United States, 33134
4
San Marcus Research Clinic
Miami Lakes, Florida, United States, 33104