Status:
RECRUITING
IMV to Accelerate Recovery of Lung Function in Veno-venous Extracorporeal Membrane Oxygenation; Lung Rest Or Moderate Mechanical Ventilation in ECMO
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Conditions:
ARDS
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Feasibility trial to inform a future multicentre randomized control trial. The investigators aim to evaluate the feasibility of a trial of near apnoeic ventilation (two breaths per minute) compared wi...
Detailed Description
Background Acute respiratory distress syndrome (ARDS) is a common clinical syndrome characterised by life threatening respiratory failure requiring mechanical ventilation. Although lifesaving, mechan...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Adult patients aged 18 years or older on the date of screening
- Acute and potentially reversible cause of ARDS
- Receiving invasive mechanical ventilation
- Requiring ECMO for severe ARDS
- Tidal volume ≥ 2.5ml/kg predicted body weight
- Exclusion criteria:
- Patients who meet the one or more of the following will be excluded from the trial.
- Declined consent
- \>12 hours following ECMO initiation
- Patient likely to die or for withdrawal of life sustaining therapies within 24 hours
- Use of V-A ECMO or hybrid ECMO modes
- Current pregnancy
Exclusion
Key Trial Info
Start Date :
February 22 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06006676
Start Date
February 22 2024
End Date
March 1 2026
Last Update
February 28 2024
Active Locations (1)
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1
Guys & St. Thomas' NHS Foundation Trust
London, United Kingdom, SE1 7EH