Status:
COMPLETED
The Impact of the Physiological Response to Sugar on Brain Activity and Behavior
Lead Sponsor:
Virginia Polytechnic Institute and State University
Conditions:
Food Preferences
Appetitive Behavior
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
The goal of this pilot study is to test the feasibility of assessing how biological factors and chemical properties of sugars may influence metabolism and food reward in humans. The main questions it ...
Detailed Description
Prior studies in humans indicate that while energy expenditure response is similar after consumption of equal amounts of fructose, glucose, and sucrose (a dimer of glucose + fructose), carbohydrate ox...
Eligibility Criteria
Inclusion
- BMI between 18.5-25 kg/m2
- Not pregnant or planning to become pregnant during study participation
- Residing in the Roanoke area and/or willing/able to attend sessions at the Fralin Biomedical Research Institute (FBRI) at Virginia Tech Carilion
- Weigh at least 110 lbs
Exclusion
- Current inhaled nicotine use
- History of alcohol dependence.
- Current or past diagnosis of cardiometabolic disease or problems, including diabetes, endocrine, heart, or thyroid problems, that may influence study outcomes
- Hemoglobin A1C \>5.7%
- Taking medications known to influence study measures (including attention-deficit/hyperactivity disorder (ADHD), allergy, antidepressant, antipsychotic, anxiolytic, birth control, blood pressure, blood glucose, cholesterol, thyroid, sleep, or weight loss medications)
- Active medical or neurologic disorder, including cardiometabolic conditions or gastrointestinal conditions that may influence study outcomes
- Recent change in body weight (gain or loss of \> 5 lbs within the past 3 months)
- Current shift work (typical pattern of work/activity overnight)
- Previous weight loss surgery
- Adherence to a special diet within the past 3 months (e.g., low-carb or ketogenic diet, exclusion of food groups/specific macronutrients, intermittent fasting, etc.)
- Allergy to any food or ingredient included in the study diets, meals, or beverages
- Currently pregnant or planning to become pregnant during study participation
- Claustrophobia
- Contraindications for MRI, including pacemaker, aneurysm clips, neurostimulators, cochlear or other implants, metal in eyes, regular work with steel, etc. (Note: This is an fMRI-specific exclusion criterion. Participants may be allowed to participate in all other study sessions and measures that do not involve fMRI.)
- Contraindications for bioelectrical impedance analysis, specifically implanted devices
- Use of substances (or combinations of substances) in doses and frequencies that could influence neural outcomes of study.
Key Trial Info
Start Date :
September 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 22 2024
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT06015490
Start Date
September 1 2023
End Date
July 22 2024
Last Update
September 11 2025
Active Locations (1)
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1
Fralin Biomedical Research Institute at Virginia Tech Carilion
Roanoke, Virginia, United States, 24016