Status:
ACTIVE_NOT_RECRUITING
Diagnostic Strategy for Suspected Pulmonary Embolism Based on 4PEPS
Lead Sponsor:
University Hospital, Angers
Conditions:
Pulmonary Embolism
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The increased use of diagnostic imaging and especially computed tomography pulmonary angiography in patients suspected of pulmonary embolism (PE) is an important point of concerns. The goal of this p...
Detailed Description
Several strategies have been devised to safely limit the use of thoracic imaging in patients suspected of pulmonary embolism (PE). However, they are based on different rules for clinical probability (...
Eligibility Criteria
Inclusion
- Admission to an emergency department participating in the study.
- Suspected PE due to thoracic symptoms (dyspnea, chest pain, or hemoptysis) and/or syncope without any other obvious explanation after clinical examination and possible additional first-line tests (ECG, chest X-ray, or routine lab work-up).
Exclusion
- Age \< 18 years.
- Known result of a specific diagnostic imaging examination for PE (thoracic CT angiography, pulmonary scintigraphy, or venous ultrasound of the lower limbs).
- Hemodynamic instability (systolic blood pressure \< 90 mmHg or more than 40 mmHg lower than usual for more than 15 min).
- Curative dose of anticoagulant in place for more than two days prior to inclusion.
- Pregnant or parturient patient.
- Patient in detention by judicial or administrative decision.
- Patient undergoing compulsory psychiatric treatment.
- Patient placed under a legal protection measure.
- Patient who objects to participating in the research (preliminary phase) or is unable to give free and informed consent (active phase).
Key Trial Info
Start Date :
November 29 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2025
Estimated Enrollment :
2951 Patients enrolled
Trial Details
Trial ID
NCT06015529
Start Date
November 29 2023
End Date
September 1 2025
Last Update
September 19 2025
Active Locations (23)
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1
Cliniques Bruxelles
Brussels, Belgium
2
CHU Liège
Liège, Belgium
3
CH Agen
Agen, France
4
CHU Angers
Angers, France, 49000