Status:
RECRUITING
Predictive Value of Serum and Tissue Molecular Markers and Imaging Features in the Invasiveness and Prognosis of Pituitary Neuroendocrine Tumors
Lead Sponsor:
Sun Yat-sen University
Conditions:
Pituitary Adenoma
Neuroendocrine Tumors
Eligibility:
All Genders
18-70 years
Brief Summary
As the clinical manifestations of pituitary neuroendocrine tumors vary greatly, 2.7-15% of them are resistant to conventional treatments such as surgery, drug therapy and radiotherapy, and often relap...
Eligibility Criteria
Inclusion
- Patients with pituitary neuroendocrine tumors: pituitary adenoma was diagnosed by clinical imaging, with or without pituitary hormone secretion function was confirmed by pituitary hormone detection.
Exclusion
- Previous pathological specimen suggested pituitary carcinoma.
- always have received radiation and chemotherapy or immune and targeted therapy of the patients.
- with known genetic syndrome can cause excessive secretion of hormones (such as Carney syndrome, McCune - Albright syndrome, multiple endocrine neoplasia type 1, acute interstitial pneumonia) patients.
- there are ectopic neuroendocrine tumor patients.
- within one month before the screening for major surgery, or within 3 months before screening for patients with sphenoid pituitary surgery.
- crisis of gland function (the pituitary gland, thyroid crisis, adrenal crisis).
- peripheral glands or other solid tumors in patients with severe disease or blood system.
- serious organ damage such as heart, kidney, liver, etc.
- with severe mental or nervous system disease.
- serious high blood glucose or poorly controlled hypertension or emergency patients.
Key Trial Info
Start Date :
April 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2029
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06015802
Start Date
April 1 2021
End Date
March 1 2029
Last Update
August 29 2023
Active Locations (1)
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1
endocrinology department of the first affiliated hospital of Sun Yat-sen University
Guangzhou, Guangdong, China, 510080