Status:
COMPLETED
Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure.
Lead Sponsor:
Johannes Grand
Conditions:
Acute Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
Intravenous (IV) loop diuretics have been a key component in treating pulmonary edema since the 1960s and has a Class 1 recommendation in the 2021 guidelines for acute heart failure. However, no rando...
Detailed Description
Prospective observational study of the acute and subacute effects of furosemide in patients with acute heart failure. After inclusion, 80 mg of furosemide is administered IV. Measurements include bl...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Clinical diagnosis of acute heart failure requiring hospitalization
- Systolic blood pressure ≥100 mmHg
- Oxygen saturation \<94% or need of oxygen
- Confirmed pulmonary congestion on x-ray or ReDS
Exclusion
- More than 40 mg iv furosemide within the last three hours before randomization, including prehospital administration
- Ongoing ventricular taky- or brady-arrythmias or supraventricular arrhythmias with HR \> 180 or \< 40 bpm.
- Known chronic obstructive lung disease
- Pacemaker or ICD on the right side
- Congenital heart malformations or intra-thoracic mass that would affect the right lung anatomy (e.g. dextrocardia, lung carcinoma)
- Wounds, burns, healing tissue, skin infection or recent skin graft or flap where the sensors should be attached to the skin
- Height less than 155 cm or higher than 200 cm
- BMI of less than 18 or more than 38
Key Trial Info
Start Date :
September 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 9 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06024889
Start Date
September 1 2023
End Date
February 9 2024
Last Update
February 16 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Amager-Hvidovre Hospital
Copenhagen, Capital Region of Denmark, Denmark, 2650