Status:
COMPLETED
Effects of L-citrulline Supplementation on Vascular Function in Metabolic Syndrome
Lead Sponsor:
Texas Tech University
Conditions:
Metabolic Syndrome
Menopause
Eligibility:
FEMALE
45-79 years
Phase:
NA
Brief Summary
The objective of this project is to provide evidence that L-Citrulline (CIT) supplementation can improve vascular function in the fasted and acute hyperglycemia conditions in middle-aged and older wom...
Detailed Description
Using a double-blind, randomized, placebo-controlled, and parallel design, middle-aged and older women with metabolic syndrome will be randomized into receiving either CIT supplementation (10g/day) or...
Eligibility Criteria
Inclusion
- Must present at least 3 of the following 5 cardiometabolic risk factors
- Waist circumference ≥88 cm
- Fasting glucose between 100-125 mg/dL or HbA1c between 5.7-6.4%.
- Blood pressure ≥130 mm Hg
- Triglyceride ≥ 150 mg/dL
- HDL \<50 mg/dL
- The following are also inclusion criteria's:
- Women aged 45-79 years old
- Body mass index ≤ 39.9 kg/m2
- Sedentary (defined as \< 120 min/week of exercise)
- Abstain from any dietary supplements with vascular effects for one month prior to the beginning of the study and until participation in study has terminated.
Exclusion
- \< 45 and \> 79 years of age
- Use of medications and/or any supplements that may affect outcome variables (such as arginine-containing supplements, nitroglycerin, statin drugs, biguanides, insulin, beta blockers, statins, verapamil)
- Systolic blood pressure ≥ 160 mmHg
- BMI \> 40 kg/m2
- Recent changes in medication (3 months)
- Current smoking any tobacco use
- Cardiovascular disease, diabetes (Type 1 or 2), and other metabolic or chronic diseases
- More than 7 alcoholic drinks/week of consumption
Key Trial Info
Start Date :
January 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2024
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06025357
Start Date
January 1 2023
End Date
August 1 2024
Last Update
May 15 2025
Active Locations (1)
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1
TTU Kinesiology and Sport Management Building
Lubbock, Texas, United States, 79409