Status:
RECRUITING
Cerebrovascular Health and Resilience in Midlife
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Psychological Stress
Cardiovascular Diseases
Eligibility:
All Genders
40-59 years
Phase:
NA
Brief Summary
This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions. In on...
Detailed Description
This cross-sectional study examines the extent to which cardiovascular responses to the acute experience of psychological stress relate to signs of cerebrovascular health detected on magnetic resonanc...
Eligibility Criteria
Inclusion
- Able to attend 2 study visits at the University of Pittsburgh campus in Oakland (Pennsylvania)
- Able to read and speak English
Exclusion
- Uncontrolled hypertension (systolic blood pressure \>160 or diastolic blood pressure \>100 mmHg)
- Current use of anticonvulsant, anti-Parkinson, neuroleptic, or antipsychotic medications
- Current use of glucocorticoids (e.g., oral prednisone) or ephedrine
- Current chronic conditions of the lungs, liver and kidney, as well as cancer (chemotherapy and radiation) treatment in the past 12 months (allowances are made for non-melanoma skin cancer treatment, controlled asthma, and allergy inhalers)
- Self-reported major neurological disorders or brain injuries (e.g., multiple sclerosis, cerebral palsy, major head injury)
- Self-reported psychotic illnesses (mania, bipolar disorder, schizophrenia)
- Current pregnancy or childbirth within the past 6 months
- Suspected mild cognitive impairment or dementia
- Self reported sleep apnea
- Self-reported history of myocardial infarction, stroke, or revascularization procedures, as well as treatment for cardiac arrhythmias
- Self-reported lack of comfort to undergo MRI testing
- Presence of implants or objects that are unsafe for MRI (e.g., tattooed eyeliner), as well as any other contraindications that would prevent MRI testing
- Self-reported lack of comfort to undergo the laboratory math task
Key Trial Info
Start Date :
October 17 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
450 Patients enrolled
Trial Details
Trial ID
NCT06029348
Start Date
October 17 2023
End Date
June 30 2029
Last Update
September 26 2025
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213