Status:
ACTIVE_NOT_RECRUITING
Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Solid Tumor
Cutaneous Squamous Cell Carcinoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate pathologic complete response (pCR) rate of coformulated favezelimab/pembrolizumab (MK-4280A) or pembrolizumab as assessed by blinded central pathology review (...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Cohort A only
- Histologically confirmed diagnosis of resectable cutaneous squamous cell carcinoma (cSCC) as the primary site of malignancy (metastatic skin involvement from another primary cancer or from an unknown primary cancer is not permitted)
- Stage II to Stage IV disease without distant metastasis (M1). cSCC tumors arising in the head and neck will be staged according to American Joint Committee on Cancer (AJCC) Edition (Ed.) 8 and cSCC tumors arising in non-head and neck locations will be staged according to Union for International Cancer Control (UICC) Ed. 8
- Is systemic treatment naïve
- Archival tumor tissue sample, or newly obtained surgical resection, or biopsy sample of a tumor lesion not previously irradiated has been provided
- Is an individual of any sex/gender, at least 18 years of age at the time of providing the informed consent
- Cohort B only
- Histologically confirmed diagnosis of endometrial cancer (EC) that is not deficient in mismatch repair (dMMR) proficient in mismatch repair (pMMR) as documented by a local test report
- Documented evidence of stage IVB (per 2009 International Federation of Gynecology and Obstetrics (FIGO) staging), recurrent, or metastatic EC, and are not candidates for curative surgery or radiation
- Has radiographic evidence of disease progression after 1 prior systemic, platinum-based chemotherapy regimen for EC in any setting
- Measurable disease per Response Evaluation Criteria In Solid Tumors (RECIST 1.1) by investigator (before first dose of study intervention)
- Is assigned female sex at birth, at least 18 years of age at the time of providing the informed consent
- Has adequately controlled blood pressure without antihypertensive medication
- All Cohorts
- Agrees to follow contraception guidelines if a participant of childbearing potential
- Has a life expectancy \>3 years per investigator assessment
- Has adequate organ function
- Has Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- If positive for hepatitis B, has received antiviral therapy for ≥4 weeks and undetectable viral load prior to randomization
- If positive for hepatitis C, has undetectable viral load at screening
- If positive for human immunodeficiency virus (HIV), has well-controlled HIV on a stable highly active antiretroviral therapy
- Exclusion Criteria:
- All Cohorts
- Has known hypersensitivity to active substances or their excipients including previous clinically significant hypersensitivity reaction to treatment with other monoclonal antibody (mAb)
- History of allogeneic tissue/solid organ transplant
- Cohort A only
- Received prior radiotherapy to the index lesion (in-field lesion)
- Participants for whom the primary site of cSCC was anogenital area (penis, scrotum, vulva, perianal region) are not eligible
- Cohort B
- Has had major surgery within 3 weeks prior to first dose of study interventions
- Has preexisting ≥Grade 3 gastrointestinal or non-gastrointestinal fistula
- Has urine protein ≥1 g/24 hours
- Has a left ventricle ejection fraction (LVEF) below the institutional (or local laboratory) normal range, as determined by multi-gated acquisition (MUGA) or echocardiogram (ECHO)
- Has radiographic evidence of encasement or invasion of a major blood vessel, or of intratumoral cavitation
- Has clinically significant cardiovascular disease within 12 months from first dose of study intervention
Exclusion
Key Trial Info
Start Date :
September 29 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2026
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT06036836
Start Date
September 29 2023
End Date
March 31 2026
Last Update
December 18 2025
Active Locations (44)
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1
Yale-New Haven Hospital-Yale Cancer Center ( Site 0643)
New Haven, Connecticut, United States, 06510
2
Dana-Farber Cancer Institute ( Site 0642)
Boston, Massachusetts, United States, 02215
3
Rutgers Cancer Institute of New Jersey ( Site 0635)
New Brunswick, New Jersey, United States, 08903
4
Duke Cancer Institute ( Site 0641)
Durham, North Carolina, United States, 27710