Status:
NOT_YET_RECRUITING
Relation Between NAFLD and BM DENSITY
Lead Sponsor:
Assiut University
Conditions:
NAFLD
Osteoporosis
Eligibility:
All Genders
18-50 years
Brief Summary
In general NAFLD is a common denominal for a broad spectrum of damage to the liver, which can be due to hepatocyte injury, inflammatory processes and fibrosis. This is normally seen on liver biopsy an...
Detailed Description
INTRODUCTION: In general, the prevalence of NAFLD has increased over the last 20 years. The Middle East and South America have the highest NAFLD prevalence at 31% and 32% respectively with the lowest...
Eligibility Criteria
Inclusion
- \- INCLUSION CRITERIA
- Patients above the age of 18 y.o and premenopausal females
- Patients showing any degree of fibrosis and steatosis .
- Patients suffers from obesity and its complications
- Patients with hyperlipidemia and DM
- NAFLD patients were diagnosed with an ultrasound examination or fibroscan or pathological examination to make a clear and definite diagnosis,
- all the obese participants according to body mass index (BMI)
- BMD was measured by dual energy X-ray absorptiometry.
Exclusion
- 1- Patients less than 18 y.o 2- Patients known alcohol abuser of ≥30 g/day in men or≥20 g/day in women. 3- Patients with chronic liver disease or HCC. 4- Subjects with suspected or proven any other liver disease other than NAFLD as (viral hepatitis, drug-induced liver injury, autoimmune liver disease, Wilson's disease or primary biliary cholangitis).
- 5- none of the subjects followed specific diets or therapeutic treatments that could influence BMD or liver function.
- 6- Patients with conditions known to affect bone metabolism, such as kidney, thyroid or parathyroid diseases, bone tumors 7- (iv) Postmenopausal females to avoid the increased risk of osteoporosis in those patients due to hormonal changes.
Key Trial Info
Start Date :
October 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06038253
Start Date
October 1 2023
End Date
December 1 2026
Last Update
September 15 2023
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