Status:
UNKNOWN
Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory Failure
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborating Sponsors:
Brazilian Research In Intensive Care Network
Latin American Intensive Care Network (LIVEN)
Conditions:
Respiration, Artificial
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18-110 years
Brief Summary
The goal of this observational study is to estimate the prevalence of the use of protective ventilation with low tidal volume ventilation in the transition of spontaneous ventilation modes in patients...
Detailed Description
Investigators will conduct a cohort study in Intensive Care Units (ICUs) across Latin America, aiming to include 422 patients with Hypoxemic Acute Respiratory Failure (ARF) and under invasive mechanic...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Patients with hypoxemic ARF, defined as a PaO2/FIO2 ratio \<300 mmHg, under controlled invasive mechanical ventilation, with an expected duration of MV of at least 24h.
- Patients transitioning to spontaneous ventilation modes (PSV, PAV Plus, NAVA or APRV)
Exclusion
- Tracheostomized patients.
- Decision not to maintain or add life support measures on the day of assessment (palliative care).
- Patient in ECMO.
- Air fistula or barotrauma that prevents adequate tidal volume monitoring.
- Severe injuries to the central nervous system that result in abolished or very high respiratory drive, for whom it is not possible to maintain protective tidal volume.
Key Trial Info
Start Date :
June 12 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 12 2024
Estimated Enrollment :
422 Patients enrolled
Trial Details
Trial ID
NCT06042036
Start Date
June 12 2023
End Date
October 12 2024
Last Update
November 18 2023
Active Locations (10)
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1
Sanatorio Juncal SA
Buenos Aires, Argentina
2
Hospital Municipal Boliviano Holandés, Universidad Mayor de San Andrés
La Paz, Bolivia
3
Hospital das Clínicas -HCFMUSP
São Paulo, São Paulo, Brazil, 05403010
4
Pontificia Universidad Catolica de Chile
Santiago, Chile