Status:
COMPLETED
Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis
Lead Sponsor:
University of Kansas Medical Center
Conditions:
Multiple Sclerosis
Frailty
Eligibility:
All Genders
40-65 years
Phase:
NA
Brief Summary
Study Significance: This proposed investigation is designed to examine the feasibility of an exercise-based intervention to reduce frailty in people living with MS. The proposed research will be the f...
Eligibility Criteria
Inclusion
- Subjects must be aged 40-65 years old to be enrolled in this study.
- Subjects must meet 3 of 5 frailty criteria (weight loss; exhaustion; weakness; slowness; inactivity) to be considered.
- Subjects must have a confirmed diagnosis of MS by the treating neurologist
- be free from MS relapses in the last 30 days
- have an Expanded Disability Status Scale (EDSS) score ≤ 6.0
- be fluent in spoken and written English.
Exclusion
- unable to walk unassisted for at least ten meters
- are diagnosed with other clinically important neurological conditions (such as Parkinson's Disease, epilepsy, etc.)
- exhibit severe cognitive impairment (as determined by a Mini-Cog score \<3)
- are diagnosed with active psychiatric problems.
- unstable cardiovascular conditions (e.g., malignant arrhythmias, critical mitral stenosis, clinically severe left ventricular outflow obstruction, critical proximal coronary artery stenosis)
- arthritis of the lower limbs
- acute lower back or lower limbs pain
- rheumatic and/or severe orthopedic problems that may interfere with resistance training.
Key Trial Info
Start Date :
November 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 23 2025
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT06042244
Start Date
November 20 2023
End Date
February 23 2025
Last Update
June 15 2025
Active Locations (1)
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1
Landon Center On Aging
Kansas City, Kansas, United States, 66103