Status:
RECRUITING
AM vs PM Exercise Training
Lead Sponsor:
Michigan State University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Hypertension
Eligibility:
FEMALE
55-80 years
Phase:
NA
Brief Summary
The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherap...
Detailed Description
Blood pressure has an internal rhythm associated with the 24-hr clock. Nocturnal blood pressure (BP) is a key contributor to cardiovascular health and may be improved by exercise. Moreover, the time o...
Eligibility Criteria
Inclusion
- Systolic BP equal to or greater than 130 mmHg without BP medication or greater than 120 mmHg with medication and diastolic blood pressure equal to and greater than 80 mmHg
- 55-80 years old
- Post-menopausal female
- Able to walk without assistance
Exclusion
- Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week
- Overt pulmonary disease/condition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension
- Cardiometabolic disease/condition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months
- Cancer within last 5 years
- Body mass index \>39 kg/m2
- Current smoking or vape
- Evening shift work
- uncontrolled thyroid disorder
- 2 or more falls in the last year
- Anemia within 3 months of enrollment
- Parkinson's disease
- Dementia
- Unstable angina
- Acute pulmonary embolus or infarction
- Acute myocarditis or pericarditis
- Acute aortic dissection
Key Trial Info
Start Date :
June 11 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
79 Patients enrolled
Trial Details
Trial ID
NCT06042439
Start Date
June 11 2024
End Date
July 1 2027
Last Update
September 25 2025
Active Locations (1)
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1
Michigan State University
East Lansing, Michigan, United States, 48824