Status:
RECRUITING
Impact of Pomegranate Seed Oil on Postprandial Cardiovascular Disease Risk Markers
Lead Sponsor:
University of Reading
Conditions:
Postmenopausal Women
Eligibility:
FEMALE
Up to 65 years
Phase:
NA
Brief Summary
Dietary fat plays a crucial role as a modifiable risk factor influencing both non-fasting lipaemia and vascular reactivity. Notably, the intake of dietary saturated fatty acids (SFAs) has been associa...
Eligibility Criteria
Inclusion
- Postmenopausal women who have been postmenopausal for at least 12 months.
- Aged 65 and under years
- Serum TAG \< 2.3 mmol/l
- Body mass index (BMI) between 18-35 kg/m2
- Fasting total cholesterol \< 7.5 mmol/l
- Fasting glucose concentration \<7 mmol/L
Exclusion
- Smokers
- Medical history of myocardial infarction or stroke in the past 12 months
- Diabetes (defined as fasting glucose \> 7.0 mmol/l) or other endocrine disorders
- Kidney, liver, pancreas or gastrointestinal disorder
- Hypertension (blood pressure \> 140/90 mmHg), cancer, medication for hyperlipidaemia (e.g. statins), hypertension or, inflammation
- Anaemia (\<115 g/L haemoglobin)
- Taking any dietary supplements known to influence lipids/gut microbiota (e.g. plant stanols, fish oil, phytochemicals, natural laxatives, probiotics and prebiotics)
- Drinking in excess of 14 units of alcohol per week
- Planning on a weight-reducing regime
- Parallel participation in another dietary intervention study
- Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention and metabolic study
Key Trial Info
Start Date :
July 6 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 28 2024
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT06042673
Start Date
July 6 2023
End Date
July 28 2024
Last Update
April 29 2024
Active Locations (1)
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1
Department of Food and Nutritional Sciences, University of Reading
Reading, United Kingdom, RG6 6AP