Status:
RECRUITING
Discovering New Insights Into Anorexia Nervosa: Influence of MicrObial DysbiosiS (DIAMOnDS)
Lead Sponsor:
Nantes University Hospital
Collaborating Sponsors:
Fondation de France
Conditions:
Anorexia Nervosa
Eligibility:
FEMALE
15+ years
Phase:
NA
Brief Summary
This study will investigate the link between the gut microbiota, the occurrence of the central adiposity phenotype, and the patients' fear to regain weight in anorexia nervosa.
Detailed Description
Excessive concerns about body shape and intense fear of becoming fat are among the core features of Anorexia Nervosa (AN). During refeeding, patients commonly report a disproportionate deposition of f...
Eligibility Criteria
Inclusion
- Women
- Over 15 years old and 3 months.
- Admitted in the specialized department for eating disorders of CHU Nantes for refeeding.
- With a diagnosis of anorexia nervosa at admission (restrictive or Binge-Eating-Purging type).
- Body Mass Index at admission below 16 kilogram per square meter.
- Written informed consent for patients over 18 years old/ oral informed consent from both the patient and a legal representative for patients under 18 years old.
- Affiliated with French social security system or beneficiary from such system.
Exclusion
- Pregnant and breastfeeding women.
- Who received a treatment with antibiotic/antifungal (other than local application) in the last three months.
- Who had a weight gain in the last month (5% or more of the patient's weight at admission).
- Under trusteeship or guardianship.
- Not fluent in French
- Who participate in another interventional study involving medication.
- Patients for whom stool collection or body mass composition analysis (with Dual-energy X-ray absorptiometry) couldn't be done during the first week of hospitalisation.
Key Trial Info
Start Date :
February 22 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2028
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06043154
Start Date
February 22 2024
End Date
September 30 2028
Last Update
November 14 2025
Active Locations (1)
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1
Nantes University Hospital
Nantes, France, 44093