Status:
COMPLETED
Brain and Stress Study
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
Robert Wood Johnson Foundation
Conditions:
Stress, Psychological
Motivation
Eligibility:
All Genders
25-60 years
Phase:
PHASE4
Brief Summary
Motivational deficits such as anhedonia are core to several psychiatric disorders and underlie significant functional impairment. This double-blind, placebo-controlled crossover trial of minocycline, ...
Detailed Description
This study seeks to conduct translational work that extends rich preclinical findings to the clinical domain to validate whether neuroinflammatory dysregulation is strongly tied to anhedonia. This pro...
Eligibility Criteria
Inclusion
- 25-60 years old
- Unemployed (working less than 20 hours per week)
- Have been unemployed for at least 6 months
- Seeking employment
- Having trouble finding a job (i.e., actively seeking and applying for jobs but not successful in landing a job)
- Reports greater than 5 points on Job Stress Items
- Regular access to a mobile phone
Exclusion
- Self-reported physical illnesses: diabetes, cardiovascular diseases, high blood pressure, inflammatory bowel diseases, rheumatoid arthritis, asthma, autoimmune disease, Crohn's disease, ulcerative colitis, lupus
- neurological conditions (e.g., Traumatic Brain Injury, stroke)
- pregnant (as measured by urine pregnancy screen) or breastfeeding
- current use of psychotropic medications
- Current regular recreational drug or alcohol use (i.e., 4 or more times per week)
- chronic diseases that significantly impact inflammatory markers (e.g., cancer)
- known allergies or hypersensitivities to tetracycline antibiotics, aspirin or other NSAIDs
- current antibiotic use
- regular use of steroidal or non-steroidal anti-inflammatory medications (i.e., 2 or more times a week)
Key Trial Info
Start Date :
September 12 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 19 2023
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06044090
Start Date
September 12 2022
End Date
December 19 2023
Last Update
December 18 2024
Active Locations (1)
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1
Howell Hall
Chapel Hill, North Carolina, United States, 27599