Status:
ENROLLING_BY_INVITATION
Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant Depression
Lead Sponsor:
First Affiliated Hospital of Zhejiang University
Conditions:
Treatment Resistant Depression
Visual Perceptual Weakness
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Major depressive disorder (MDD) exhibit reduced visual motor perception, which affects prognosis. Metabolic substance changes and abnormal neural activity in the middle temporal visual area (MT) media...
Eligibility Criteria
Inclusion
- Receive two or more adequate doses and courses of antidepressant drugs in different mechanisms that were not effective and had been stable for more than 6 weeks on antidepressant medication prior to enrollment, with non-responsiveness defined as a decrease in HAMD-24 score of \<50%.
- 24-item Hamilton Depression Scale (HAMD-24) ≥ 20.
- Normal or corrected to normal vision.
- Ability to complete spatial suppression psychophysical experiment.
- education background above the college degree.
- Age 18-45 years, regardless of gender.
- Right-handedness.
- Han Chinese.
- Signed a written informed consent, willing to participate in the study and be evaluated.
Exclusion
- Co-morbid other mental disorders, including: schizophrenia, mental retardation, substance dependence, etc.
- Patients with metal objects in the body or with other contraindications to PET-MRI scanning
- Patients with severe or unstable somatic diseases
- Women during pregnancy or lactation, and women of childbearing age with positive urine HCG test results during the screening period
- Benzodiazepines were taken during the experimental period
- Other conditions that, in the opinion of the investigator, exist that make participation in this clinical trial inappropriate.
Key Trial Info
Start Date :
November 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT06044324
Start Date
November 1 2023
End Date
May 1 2026
Last Update
March 18 2025
Active Locations (1)
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1
The First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China, 310000