Status:
UNKNOWN
Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures
Lead Sponsor:
Ain Shams University
Conditions:
Postoperative Pain, Acute
Eligibility:
FEMALE
18-60 years
Phase:
PHASE2
PHASE3
Brief Summary
The goal of this clinical trial is to compare the analgesic efficacy of adding dexmedetomidine versus ibuprofen to bupivacaine for intraperitoneal instillation after laparoscopic gynecological procedu...
Detailed Description
The patients will be randomly allocated by simple randomization using a computer program into two equal groups by closed envelope technique: Group 1: Bupivacaine/Ibuprofen group (BI): Patients will r...
Eligibility Criteria
Inclusion
- Patients with American Society of Anesthesiologists (ASA) physical status 1-2 scheduled for a Laparoscopic gynecological procedure.
Exclusion
- History of allergy to the medications used in the study.
- Contraindication as local infection at the site of port insertion.
- Severe cardiac (NYHA ≥Ⅲ or pulmonary dysfunction (known COPD, previous thoracic surgeries, or recent pulmonary infection).
- Severe hepatic impairment (Child C) (INR≥2, Albumin≤2.5).
- Severe Renal dysfunction (creatinine clearance \< 30).
- Neurologic, a psychiatric or mental disorder affecting the patient's ability to interpret VAS score.
- Body mass index (BMI) ≥ 40 or ≤ 18 kg/m2.
- Patients who were converted to open surgery.
- ASA Ⅲ-Ⅳ.
- Patient refusal.
- Emergency operations.
Key Trial Info
Start Date :
September 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 30 2024
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT06046105
Start Date
September 15 2023
End Date
March 30 2024
Last Update
September 21 2023
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