Status:
COMPLETED
Effect of Transcutaneous Vagus Nerve Stimulation on Upper Limb Function in Stroke Patients
Lead Sponsor:
Cairo University
Conditions:
Stroke, Ischemic
Eligibility:
All Genders
45-65 years
Phase:
NA
Brief Summary
The goal of this interventional study is to investigate the therapeutic efficacy of non-invasive vagus nerve stimulation on upper limb function in chronic stroke patients . The main question is: •Is ...
Detailed Description
Stroke causes several neurological deficits or impairments as hemiparesis, communication disorders, cognitive deficits or disorders in visuo-spatial perception. Approximately 60% of survivors after st...
Eligibility Criteria
Inclusion
- Hemiparetic patients with ischemic middle cerebral artery stroke.
- Duration of illness ranged from at least 6 months after stroke.
- The patient's age ranged from 45 to 65 years.
- Spasticity of upper limb muscles ranged from (grade 1:2) according to the Modified Ashworth scale.
- The patients with unilateral upper limb motor function impairment.
- Patients with sufficient cognitive abilities that enable them to understand and follow instructions.
Exclusion
- Patients with neurological diseases that affect upper limb function other than stroke (e.g.: Multiple sclerosis, Peripheral neuropathy, Parkinsonism….etc.).
- Hemorrhagic stroke patients.
- Patients with previous surgical intervention on the vagus nerve.
- Patients with pacemakers or other implanted electrical devices.
- Patients with a history of significant alcohol or drug abuse.
- Patients with musculoskeletal disorders such as severe arthritis, knee surgery, total hip joint replacement, lower limb fractures or contractures of fixed deformity, and leg length discrepancy after total hip replacement.
- Patients with cardiovascular problems (unstable angina, recent myocardial infarction, congestive heart failure, significant heart valve dysfunction, or unstable hypertension) or pulmonary or kidney disorders.
- Patients with visual or auditory impairment affecting their ability to complete the testing.
- Patients with cognitive impairment.
- Any current or past history of facial or ear pain, recent ear trauma, or metal implants above the level of the neck.
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 10 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06048055
Start Date
October 1 2023
End Date
April 10 2024
Last Update
April 30 2025
Active Locations (1)
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1
Faculty of physical therapy labs at Cairo University
Giza, Egypt, 12612