Status:
COMPLETED
Comparative Study Between Preoperative and Postoperative Rectal Misoprostol
Lead Sponsor:
Egymedicalpedia
Conditions:
Blood Loss, Surgical
Blood Loss, Postoperative
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Cesarean delivery (CD) is the most common major surgical procedure undergone by women around the world. Over the past two decades, there has been a witnessed increase in rates of caesarean deliveries,...
Detailed Description
In resource-limited countries, postpartum hemorrhage (PPH) remains the leading cause of maternal mortality. The increased rates of caesarean delivery have been incriminated as the primary cause behind...
Eligibility Criteria
Inclusion
- Gestational age ( 37 to 41 weeks).
- Singleton healthy fetus.
- Scheduled for elective lower segment caesarean delivery under spinal anaesthesia.
- Body mass index of (25-30 Kg/m2).
- Normal coagulation profile.
- Normal amniotic fluid volume assessed by amniotic fluid index.
Exclusion
- Maternal comorbidity: Hypertension; diabetes; heart, kidney, or liver disorders.
- Contraindication to use of misoprostol like known allergy to misoprostol or asthmatic patients.
- Women who had undergone any previous uterine surgery such as myomectomy because it is considered upper uterine segment operation with more destruction in myometrium but caesarean section is a lower segment uterine operation with minimal destruction in myometrium.
- Women at higher risk of intraoperative blood loss or PPH, such as those with hemoglobin levels less than 9 g/dl, history of PPH, or uterine fibroids.
- Antepartum hemorrhage ( placenta previa and placental abruption).
- Women who will undergo caesarean section because of failure of induction of labor.
Key Trial Info
Start Date :
August 31 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2023
Estimated Enrollment :
128 Patients enrolled
Trial Details
Trial ID
NCT06049160
Start Date
August 31 2023
End Date
November 30 2023
Last Update
August 20 2024
Active Locations (1)
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1
Faculty of medicine, Cairo University
Cairo, Egypt