Status:
RECRUITING
Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity
Lead Sponsor:
Australian and New Zealand Intensive Care Research Centre
Conditions:
Critical Illness
Obesity
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The DIRECT trial is a prospective, multi-centre, two arm parallel feasibility pilot randomised controlled trial. The primary aim is to determine the feasibility of using repeat indirect calorimetry me...
Detailed Description
Indirect calorimetry is the current reference standard for measuring energy expenditure during critical illness, allowing for personalisation of energy delivery. Use of indirect calorimetry may be imp...
Eligibility Criteria
Inclusion
- Adult (≥ 18 years) patients
- Body mass index ≥30 kg/m2
- Between day 3 and 6 of index ICU admission
- Receiving invasive mechanical ventilation
- Receiving enteral or parenteral nutrition
Exclusion
- Receiving extracorporeal membrane oxygenation support
- Major burns (≥20% total body surface area)
- Unable to perform indirect calorimetry within 24 hours of randomisation
- Known pregnancy
- Death is imminent
- Treating clinician believes the study is not in the best interest of the patient
Key Trial Info
Start Date :
October 2 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06053216
Start Date
October 2 2023
End Date
June 1 2026
Last Update
July 25 2025
Active Locations (5)
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1
Blacktown Hospital
Blacktown, New South Wales, Australia, 2148
2
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
3
Ballarat Base Hospital, Grampians Health
Ballarat Central, Victoria, Australia, 3550
4
The Alfred Hospital
Melbourne, Victoria, Australia, 3004