Status:
RECRUITING
Spatial-Motor Stroke-Rehab Study
Lead Sponsor:
Emory University
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Spatial Neglect
Stroke
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The purpose of this study is to understand how prism adaptation training with and without electrical stimulation changes visuospatial behavior, motor system neurophysiology, and walking dysfunction.
Detailed Description
Spatial Neglect (SN) is defined as pathological asymmetric spatial behavior causing functional disability and occurs in greater than 50% of individuals with right hemisphere stroke. SN post-stroke is ...
Eligibility Criteria
Inclusion
- Young Adults Able Bodied (YAB) Individuals
- 18-30 years
- Able-Bodied (healthy without any physical disability or neurological disorder)
- Older Adults Able-Bodied Individuals (OAB)
- 45-90 years
- Able-Bodied (healthy without any physical disability or neurological disorder)
- Individuals with right hemisphere stroke (40-90 years)
- \>3 months following stroke.
- Presence of Aiming SN
- Ability to walk \>10m with or without assistive devices.
- Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4/5 on the Medical Research Council Scale
- Ability to follow 3-stage commands and provide informed consent.
Exclusion
- Young Adults Able Bodied (YAB) Individuals and Older Adults Able-Bodied Individuals (OAB)
- History or evidence of orthopedic or physical disability
- History or evidence of neurological pathology
- Pregnancy (female)
- Uncontrolled hypertension
- Cardiac pacemaker or other implanted electronic system
- Presence of skin conditions preventing electrical stimulation setup
- Impaired sensation in the left upper limb.
- Bruises or cuts at the stimulation electrode placement site
- Concurrent enrollment in rehabilitation or another investigational study.
- History or evidence of orthopedic or physical disability interfering with study procedures
- History or evidence of neurological pathology or disorder
- Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures
- Contraindications to TMS such as metal implants, medications that can increase cortical excitability, unexplained dizziness in the past 6 months
- Individuals with right hemisphere stroke (40-90 years)
- History of multiple strokes or brainstem strokes
- Cerebellar disorders
- Impaired sensation in the left upper limb.
- History of other neurological disorders
- Uncontrolled hypertension
- Cardiac pacemaker or other implanted electronic system
- Pregnancy (female)
- Presence of skin condition
- Bruises at the electrode placement site
- Concurrent enrollment in rehabilitation or another investigational study
- Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) or other medical conditions that can interfere with study procedures
- Contraindications to TMS such as metal implants in the brain, medications that will increase cortical excitability, etc.
Key Trial Info
Start Date :
April 11 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT06053320
Start Date
April 11 2023
End Date
March 1 2026
Last Update
October 16 2025
Active Locations (3)
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1
Emory Rehabilitation Hospital
Atlanta, Georgia, United States, 30322
2
Emory University Hospital (EUH)
Atlanta, Georgia, United States, 30322
3
Executive Park
Atlanta, Georgia, United States, 30329