Status:
NOT_YET_RECRUITING
Testing Regional anesthesia Techniques For Up And Early Discharge Following Knee arthroplasty - a Feasibility Study
Lead Sponsor:
McMaster University
Conditions:
Arthroplasty, Replacement, Knee
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
To assess feasibility of a a trial investigation postoperative patient-reported quality of recovery after total knee arthroplasty (TKA) with periarticular joint injection (PAI) ± single shot adductor ...
Detailed Description
Knee osteoarthritis (KOA) is a leading cause of chronic knee pain and disability, with a lifetime prevalence of 45%. Treatment for symptomatic KOA includes physical therapy, oral anti-inflammatory med...
Eligibility Criteria
Inclusion
- All adult patients presenting for a primary TKA.
Exclusion
- Age \<18 years;
- Body mass index ≥45 kg/m2;
- Weight \<80 kg;
- Deemed unsuitable for regional anesthesia;
- Planned general anesthesia;
- Hepatic insufficiency/Intolerance to acetaminophen;
- Renal insufficiency (defined by estimated glomerular filtration rate \<60 mL/min/1.73 m2);
- Chronic opioid use (individuals requiring the equivalent of 1 mg or more of intravenous morphine, or 3 mg or more of oral morphine per hour for greater than 1 month);
- Allergy or intolerance to study medications (listed under 'Spinal and Adductor Canal Block') or trial medications listed in "Postoperative" section and "standard prescription"
- Clinical Frailty Scale score ≥4;
Key Trial Info
Start Date :
January 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
226 Patients enrolled
Trial Details
Trial ID
NCT06054750
Start Date
January 1 2025
End Date
June 30 2027
Last Update
October 22 2024
Active Locations (1)
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1
St Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8N 4A6