Status:
RECRUITING
Use of Pulsed Low-dose Rate Re-irradiation for Recurrent Glioma (PULSAR)
Lead Sponsor:
Centro di Riferimento Oncologico - Aviano
Conditions:
Glioma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Re-irradiation in gliomas is a therapeutic option at recurrence before of 2nd-line chemotherapy. The dose of re-irradiation with conventional fractionation is unfortunately limited by the risk of symp...
Eligibility Criteria
Inclusion
- Age ≥18 years;
- Ability to express appropriate informed consent to treatment;
- Diagnosis of cerebral glioma;
- Histological/radiological confirmation of disease recurrence/relapse;
- Previous brain-level radiation therapy completed a minimum of 6 months;
- Performance status: ECOG=0-2.
Exclusion
- Refusal to radiation treatment (i.e., absence of informed consent signed);
- Concomitant chemotherapy;
- Leptomeningeal spread of disease and localization in both cerebral hemispheres;
- Current pregnancy.
Key Trial Info
Start Date :
May 26 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 26 2028
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT06055517
Start Date
May 26 2023
End Date
May 26 2028
Last Update
September 26 2023
Active Locations (1)
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1
IRCCS-Centro di Riferimento Oncologico (CRO) di Aviano
Aviano, Pordenone, Italy, 33081