Status:
RECRUITING
Methadone Pharmacokinetics in End-stage Renal Disease
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Conditions:
Chronic Kidney Diseases
Post Operative Pain
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to describe the influence of renal function on the pharmacokinetics of methadone used through an intravenous patient-controlled analgesia (IV-PCA) pump for the ...
Detailed Description
This study will be carried out at the Pontifical Catholic University of Chile Hospital with prior approval by the ethics committee. Study staff will assess the inclusion criteria, obtain informed cons...
Eligibility Criteria
Inclusion
- Patients with chronic kidney disease (CrCl 15-60 ml/min)
- Patients over 18 years old undergoing surgery requiring general anesthesia with subsequent use of intravenous methadone patient-controlled analgesia
- Hospital stay ≥ 48 hours
- Body mass index 18-35 kg/m2
Exclusion
- History of liver disease
- Need for dialysis (hemo or peritoneal dialysis)
- Use of home oxygen therapy
- American Society of Anesthesiologists (ASA) physical status IV-V
- Pregnancy
- Chronic opioid use
- Methadone allergy
- Prolonged QT interval
- Use of antiarrhythmics that prolong the QT interval
- Inability to understand the proper use of PCA
Key Trial Info
Start Date :
April 5 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06056245
Start Date
April 5 2024
End Date
December 31 2024
Last Update
May 10 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Pontificia Universidad Católica de Chile
Santiago, Chile, 7550000