Status:
NOT_YET_RECRUITING
IMaC - Immune Pathways in Oesophagogastric Cancer
Lead Sponsor:
Royal Marsden NHS Foundation Trust
Collaborating Sponsors:
Imperial College London
Conditions:
Oesophagogastric Cancer
Eligibility:
All Genders
17+ years
Brief Summary
The number of cases of oesophagogastric cancer is increasing every year. Currently, only 39% of patients with oesophageal cancer can have potentially curative treatment by the time they are diagnosed....
Detailed Description
The purpose of this study is to investigate the interplay between immune pathways, the mucosal barrier and microbiome in oesophagogastric cancer, with the intention of identifying biologically-plausib...
Eligibility Criteria
Inclusion
- Adult patients \>16 years old
- Referred for oesophago-gastro-duodenoscopy (OGD) to investigate any of the following;
- Symptoms including difficulty swallowing, vomiting, reflux symptoms including heartburn, anaemia, GI bleeding, upper abdominal pain and weight loss.
- Oesophagitis, gastritis or GORD.
- Barrett's oesophagus (BO) requiring surveillance or endoscopic therapy.
- Histologically confirmed OGc undergoing further investigation as part of staging such as laparoscopy and OGD or undergoing surgical resection (oesophagectomy/gastrectomy) as part of their treatment.
Exclusion
- Cancers other than adenocarcinoma or squamous cell carcinoma, including but not limited to gastro-intestinal stromal tumours (GIST), mucosa associated lymphoid tissue lymphoma (MALT lymphoma) and carcinoid tumours.
- Patients with recurrent OGc.
Key Trial Info
Start Date :
October 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
310 Patients enrolled
Trial Details
Trial ID
NCT06057220
Start Date
October 1 2023
End Date
September 1 2026
Last Update
October 5 2023
Active Locations (3)
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1
Royal Surrey County Hospital
Guildford, United Kingdom, GU27WG
2
St Georges University Hospital
London, United Kingdom, SW17 0QT
3
The Royal Marsden NHS Foundation Trust
London, United Kingdom, SW36JJ