Status:
RECRUITING
RNA as Prognostic Biomarkers in Patients With Acute Coronary Syndrome
Lead Sponsor:
IRCCS Policlinico S. Donato
Conditions:
Coronary Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
Identify circulating protein-coding (mRNAs) or non-coding (ncRNAs) transcripts (ACS\_signature) predictive of ventricular dysfunction in ACS patients undergoing PCI.
Detailed Description
Perform an observational, prospective study involving the evaluation of circulating biomarkers predictive of ventricular dysfunction (FE \<45%) in patients with ACS. In particular, will be to verify ...
Eligibility Criteria
Inclusion
- Age \>18 years
- Patients with ACS (first episode), defined according to the guidelines of the European Society of Cardiology (ESC) 2017
- Indication for percutaneous revascularization treatment
- Informed consent to study enrollment
Exclusion
- Severe valve disease or other conditions requiring cardiac surgery
- Previous cardiac surgery including coronary artery bypass grafts
- Total chronic occlusions
- Patients with known hypersensitivity or contraindication to any of the following drugs:
- heparin
- aspirin,
- clopidogrel,
- ticlopidine,
- sirolimus,
- everolimus.
- Any contraindication to drug-eluting stent implantation (DES)
- Patients with a documented history of myocardial infarction;
- Left ventricular ejection fraction (LVEF) \<30% before PCI
- Patients in cardiogenic shock
- Patients with advanced ST-segment elevation myocardial infarction (\> 48 h from onset of symptoms/Q waves on electrocardiogram) or undergoing fibrinolysis;
- Patients with prior known cardiomyopathy with LVEF \< 40%
- Patients with malignant neoplasm or systemic disease with quoad vitam prognosis less than 1 year;
- Patients with known active infectious diseases;
- Patients who are unable to express valid informed consent to the act of enlistment
- Pregnant women
Key Trial Info
Start Date :
July 13 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 30 2027
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06058182
Start Date
July 13 2020
End Date
January 30 2027
Last Update
October 6 2023
Active Locations (1)
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1
IRCCS Policlinico S. Donato, Milan, Italy
Milan, Milan, Italy, 20097