Status:
COMPLETED
Standardised Drug Provocation Testing in Perioperative Hypersensitivity
Lead Sponsor:
University Hospital, Antwerp
Conditions:
Allergic Reaction
Hypersensitivity
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to evaluate the safety and outcome of systematic drug provocation testing with anaesthetics at therapeutic doses in adult patients undergoing diagnostic work-up for ...
Detailed Description
Perioperative hypersensitivity reactions (POH) pose a risk for major morbidity and mortality in the perioperative period. After resolution of the initial reaction it is crucial to determine the culpri...
Eligibility Criteria
Inclusion
- patients consulting the allergology department of the Antwerp University hospital medical with a history consistent with perioperative hypersensitivity
- Indication for diagnostic work-up as determined at an interdisciplinary meeting between allergologists and anaesthetists
- willing to sign separate informed consent forms for both general anaesthesia and the Drug Provocation Test.
Exclusion
- patient refusal
- incomplete diagnostic work-up
- history inconsistent with perioperative hypersensitivity
Key Trial Info
Start Date :
October 23 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06065137
Start Date
October 23 2023
End Date
June 30 2025
Last Update
September 8 2025
Active Locations (1)
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1
Antwerp University Hospital
Edegem, Antwerp, Belgium, 2650