Status:
RECRUITING
miRNAs in Critical Limb Ischemia (miRNACLI)
Lead Sponsor:
IRCCS Policlinico S. Donato
Conditions:
Critical Limb Ischemia
Eligibility:
All Genders
40-85 years
Brief Summary
For the present study, 40 patients affected by critical limb ischemia of different severity will be enrolled: patients affected by critical limb ischemia undergoing subgenual femoropopliteal bypass; p...
Detailed Description
The analyzes of the expression of miRNAs and the RISC complex will be carried out on fragments of skeletal muscle taken from different sites depending on whether they are cases or controls. Cases: *...
Eligibility Criteria
Inclusion
- Cases:
- patients affected by CLI candidates for popliteal exploration surgery and/or subgenual femoropopliteal bypass.
- Patients affected by CLI with irreversible ischemia and/or distal gangrene of the lower limb candidates for major amputation of the lower limb.
- Controls:
- • patients affected by infrarenal abdominal aortic aneurysm (AAA) undergoing endovascular exclusion surgery of the AAA (EVAR) who are free from CLI, affected and not affected by type 2 diabetes mellitus.
Exclusion
- Pregnant women
- Patients carriers of genetic diseases
- Patients suffering from malignant neoplasia
Key Trial Info
Start Date :
May 31 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 31 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06066268
Start Date
May 31 2016
End Date
May 31 2026
Last Update
April 30 2025
Active Locations (1)
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1
Irccs Policlinico San Donato
San Donato Milanese, Milan, Italy, 20097