Status:
UNKNOWN
SALT for Treatment of Patients With Early ACLF
Lead Sponsor:
RenJi Hospital
Conditions:
Acute-On-Chronic Liver Failure
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
ACLF is a syndrome characterized by rapid deterioration of liver function in chronic liver disease or undiagnosed chronic liver disease, with a high risk of short-term death. Both CMA and EASL mention...
Detailed Description
Acute on chronic liver failure (ACLF) is a type of liver failure that was considered an independent disease in 1995. It causes acute liver injury on the basis of chronic liver disease, leading to acce...
Eligibility Criteria
Inclusion
- Age 18-70 years old
- Diagnosed as acute-on-choronic liver failure according to APASL definition
- The severity of chronic and acute liver failure is diagnosed as level 1-2 according to the CANONIC criteria
- Signed informed consent and expected cooperation of the patients for treatment and follow up.
Exclusion
- Clinical Frailty Scale score ≥ 7 points
- Severe hepatopulmonary syndrome, moderate to severe portal pulmonary hypertension; Surgical procedures with high risk of cardiovascular and pulmonary diseases
- Complicated with sepsis, various site infections such as spontaneous peritonitis, biliary tract infections, lung infections, bloodstream infections, urinary system infections, etc., did not improve after 72 hours of anti infection before transplantation; Gram negative bacterial infections resistant to carbapenems within the past 3 months
- Grade III-IV hepatic encephalopathy (West Haven classification), shock (with a dose of more than 1ug/Kg/min for demethylated kidney), PaO2/FiO2 value ≤ 150mmHg, renal failure requiring dialysis treatment
- Lactic acid greater than 9umol/L
- Special types of anatomical variations (such as portal vein III-IV type, etc.)
- Severe mental and psychological disorders
- Complicated with other diseases such as AIDS or malignant tumors
- Any reason why, in the opinion of the investigator, the patient should not participate
Key Trial Info
Start Date :
October 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06069037
Start Date
October 15 2023
End Date
December 30 2025
Last Update
October 5 2023
Active Locations (1)
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1
Renji Hospital, Shanghai Jiao Tong University, School of Medicine
Shanghai, China, 200127