Status:
RECRUITING
Project 4: ACHIEVE PATHFINDER
Lead Sponsor:
Henry Ford Health System
Collaborating Sponsors:
Wayne State University
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry...
Detailed Description
Project 4 of ACHIEVE GREATER aims to improve outcomes for symptomatic (Stage C) HF. This is vitally important because HF is the most common final manifestation of cardiometabolic diseases in the U.S.,...
Eligibility Criteria
Inclusion
- Currently in the emergency room or hospitalized with plan to be discharged to home, or
- Diagnosis of heart failure
- BNP\>200 ng/L or NTproBNP\>1000 ng/L during hospitalization or within 1 month prior to screening
- Expected ability to fully participate in study (can tolerate study processes, no long travel)
Exclusion
- Hemodialysis dependent
- If dialysis is being considered by participant's care team and their eGFR value is \<30 mL/min/1.73 sq m
- Life expectancy of less than one year
- Inability to provide written informed consent
- Age less than 18 years old
- Patients with a left ventricular assist device (LVAD)
- Heart transplant recipients
- Individuals who regularly use a HEPA air cleaner in their home at screening
- Current smokers of nicotine or marijuana
- Severe aortic or mitral valve disease
- Has a scheduled, non-diagnostic cardiac procedure within 30 days prior, or in the next 90 days from screening (e.g. PCI, resynchronization, any cardiac surgery)
- If the PI decides for any reason that participation in the trial is not in the best interest of the patient
Key Trial Info
Start Date :
December 18 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT06070428
Start Date
December 18 2023
End Date
June 1 2027
Last Update
July 17 2025
Active Locations (1)
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1
Henry Ford Health
Detroit, Michigan, United States, 48202