Status:
COMPLETED
Hemodynamic Effects of Variations in Net Ultrafiltration Rate During Continuous Renal Replacement Therapy.
Lead Sponsor:
Centre Hospitalier Universitaire de Nīmes
Conditions:
Fluid Overload
Hemodynamic Instability
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Net ultra filtration (NUF) is one of the most important parameters during renal replacement therapy (RRT) whose role is to control fluid balance by water removal. To our knowledge, there are no prosp...
Detailed Description
Renal renal replacement therapy (RRT) for severe acute kidney injury is one of the most widely used life-support techniques in intensive care. One of its main functions is to maintain the water balanc...
Eligibility Criteria
Inclusion
- Patients hospitalised in the intensive care unit of one of the two participating centres
- Patients with Kidney Disease: Improving Global Outcomes 3 (KDIGO3) acute kidney injury (AKI) requiring a continuous RRT during their stay in the intensive care unit, regardless of the aetiology of the AKI
- Need to prescribe water loss by net ultrafiltration (NUF), defined by at least one of the following sub-criteria:
- weight gain ≥ 1 kg relative to entry weight
- oligo-anuria ≥ 24 hours
- clinical impact of fluid overload as judged by the clinician: acute lung oedema clinical or at CT-scan, difficulty of weaning from mechanical ventilation.
- Hemodynamic stability in the 2 hours preceding the start of NUF, defined by all of the following sub-criteria:
- absence of vasopressors (noradrenaline) or stability or reduction in their dosage
- no need for resuscitative fluids as judged by the clinician
- Patient or his/her trusted support person/legal representative/family member having given free and informed consent, and having signed the consent form or patient included in an emergency situation.
- Patient affiliated to or benefiting from a health insurance scheme.
Exclusion
- Patient moribund, with life expectancy too low to benefit from treatment, or with decision to discontinue treatment
- Patient participating in an another interventional study
- Patient in exclusion period determined by another study
- Patient under court protection or guardianship
- Patient/trusted person/legal representative/family member for whom it is impossible to give informed information.
- Pregnant, parturient or breast-feeding patient.
Key Trial Info
Start Date :
October 6 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 8 2025
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT06071026
Start Date
October 6 2023
End Date
July 8 2025
Last Update
November 17 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Centre Hospitalier Universitaire de Nîmes
Nîmes, France