Status:
COMPLETED
Does Biological Sex Influence Insulin Sensitivity and Muscle Metabolism Following High-intensity Interval Exercise?
Lead Sponsor:
University of Toronto
Conditions:
Exercise
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
High-intensity interval exercise (HIIE) is a type of exercise that involves alternating periods of intense exercise with periods of rest. HIIE has been shown to improve many aspects of cardiovascular ...
Detailed Description
The primary purpose of this study is to determine if biological sex influences the effects of high-intensity interval exercise (HIIE) on insulin sensitivity and muscle mechanisms. The investigators wi...
Eligibility Criteria
Inclusion
- 18-35 yrs
- VO2peak considered recreationally active as defined as 'fair' or 'good' (males: 41.6- 50.5ml/kg/min; females: 35-41.9 ml/kg/min) based on Canadian Society for Exercise Physiology (CSEP) normative fitness values.
- BMI between 18-27 kg/m2
- 1-3 structured exercise sessions/week, and not training for any specific sport
- Weight stable (within ± 2kg for at least 6 months)
- Eumenorrheic (female only), defined as menstrual cycle lengths ≥ 21 days and ≤ 35 days resulting in 9 or more consecutive periods per year)
- Non-smoker
Exclusion
- Diagnosed with cardiovascular or metabolic disease, hyper- or hypogonadism, and/or polycystic ovarian syndrome (PCOS)
- The use of medication for managing blood glucose or lipid metabolism
- Current use of oral contraceptives or use within the last 3 months
- Irregular menstrual cycles (\<21 days or \>35 days)
- Pregnant, lactating, or menopausal
- Recreational smoking of any kind
- Inability to perform the study exercise protocols or follow the pre-trial dietary or physical activity controls
- Taking medications affecting substrate metabolism (corticosteroids or nSAIDs)
- Actively engaging in a low-carbohydrate diet (e.g., ketogenic, Atkins)
Key Trial Info
Start Date :
October 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 26 2025
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06074003
Start Date
October 15 2023
End Date
June 26 2025
Last Update
August 19 2025
Active Locations (1)
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1
Goldring Centre for High Performance Sport
Toronto, Ontario, Canada, M5S2C9