Status:
RECRUITING
Neural Control of Breathing in Parkinson's Disease
Lead Sponsor:
Radboud University Medical Center
Conditions:
Parkinson Disease
Eligibility:
All Genders
18+ years
Brief Summary
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder. Many individuals with PD experienc...
Detailed Description
Rationale: Parkinson's disease (PD) is a progressive neurological disorder, characterised by loss of dopaminergic neurons. Respiratory dysfunction is common in patients with PD and can lead to pneumon...
Eligibility Criteria
Inclusion
- Healthy subjects: competent adult (\>18 years) volunteers
- Patients: adult (\<18 years) patients with Parkinson's disease, clinically confirmed by a movement disorder specialised neurologist with Hoehn and Yahr staging 1 to 3
- Willingness and ability to understand nature and content of the study
- Ability to participate and comply with study requirements
Exclusion
- Healthy subjects: previous or ongoing diseases of the central nervous system
- Patients: previous or ongoing diseases of the central nervous system, other than Parkinson's disease
- History of or current psychiatric treatment
- History of or current brain surgery or epilepsy, unclusing deep brain stimulation
- Neuromuscular disorders
- Pre-existing pulmonary disease, such as chronic obstructive pulmonary disease, asthma or pulmonary fibrosis
- TMS incompatibility (metal parts in head or neck, skin allergies)
- Implanted cardiac pacemaker or defibrillator, neurostimulator, cochlear implant or medical infusion device
- Large or ferromagnetic metal parts in the head (exept for a dental wire)
- Pregnancy
- Smoking
Key Trial Info
Start Date :
October 30 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06074614
Start Date
October 30 2023
End Date
May 1 2025
Last Update
December 20 2024
Active Locations (1)
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1
Radboudumc
Nijmegen, Gelderland, Netherlands, 6500 HB