Status:
UNKNOWN
Untargeted Metabolomics for Primary Aldosteronism
Lead Sponsor:
Liverpool University Hospitals NHS Foundation Trust
Conditions:
Primary Aldosteronism
Eligibility:
All Genders
18-120 years
Brief Summary
Primary aldosteronism (PA) is a common and likely under-diagnosed cause of secondary hypertension with associated cardiovascular morbidity and mortality. Current diagnosis comprises screening, confirm...
Detailed Description
Participant Recruitment * Suitable participants will be identified by members of their care teams, for whom screening, confirmatory testing and lateralisation will be / have been completed at LUHFT. ...
Eligibility Criteria
Inclusion
- Screening for PA to be performed in people with:
- sustained blood pressure (BP) above 150/100 mm Hg on each of three measurements obtained on different days, with hypertension (BP \>140/90 mm Hg) resistant to three conventional antihypertensive drugs (including a diuretic), or controlled BP (\<140/90 mm Hg) on four or more antihypertensive drugs.
- hypertension and spontaneous or diuretic-induced hypokalaemia.
- hypertension and adrenal incidentaloma.
- hypertension and sleep apnoea.
- hypertension and a family history of early onset hypertension or cerebrovascular accident at a young age (\<40 years).
- all hypertensive first-degree relatives of people with PA.
- Subset of people being screened for PA who are eligible for inclusion in this study:
- 18 years of age or older.
- People under the care of LUHFT.
- Able to give informed consent.
- Having lithium heparin plasma samples collected as part of their routine care.
Exclusion
- Under 18 years of age.
- Unable to give informed consent.
- Insufficient clinical/biochemical/radiological/histological information to accurately assign patients to PA or non-PA subsets.
Key Trial Info
Start Date :
January 19 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 19 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06076473
Start Date
January 19 2023
End Date
January 19 2025
Last Update
February 15 2024
Active Locations (1)
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1
Liverpool University Hospitals NHS Foundation Trust
Liverpool, Merseyside, United Kingdom, L9 7AL