Status:
COMPLETED
Mechanisms of Treatment Effects Using Cultured, Allogeneic Mesenchymal Stromal Stem Cells (MSCs) in Knee Osteoarthritis
Lead Sponsor:
University Medical Centre Ljubljana
Collaborating Sponsors:
Blood Transfusion Centre of Slovenia
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
50-75 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to pharmacologically evaluate the effects of culturued allogeneic umbilical cord blood-derived mesenchymal stromal stem cell (UCB-MSCs) in the treatment of end-stage...
Eligibility Criteria
Inclusion
- Patients with end-stage (Kellgren-Lawrence) knee osteoarthritis scheduled for knee arthroplasty
- Osteoarthritis of primary or post-traumatic etiology
Exclusion
- Secondary arthritis of other etiology
- Rheumatic diseases
- Uncontrolled metabolic disorders
- Crystalopathies
- Coagulopathy
- Anticoagulant therapy
- Heart failure
- Renal failure
- Other conditions that may affect immune response or pose additional risk during cell application
Key Trial Info
Start Date :
November 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06078059
Start Date
November 1 2022
End Date
December 1 2024
Last Update
December 9 2024
Active Locations (1)
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1
University medical centre Ljubljana
Ljubljana, Slovenia, 1000