Status:
COMPLETED
Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis
Lead Sponsor:
University Hospital, Basel, Switzerland
Collaborating Sponsors:
ETH Zurich (Switzerland)
Conditions:
Brown Adipose Tissue
Metabolic Disease
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
To test the hypothesis that active BAT improves metabolic health by buffering postprandial metabolites plasma metabolites and energy expenditure will be compared in volunteers with and without active ...
Detailed Description
In this prospective interventional study healthy individuals will be screened for presence of active BAT: Maximal BAT activity will be achieved by a mild cold stimulus over 2 hous and quantified by 18...
Eligibility Criteria
Inclusion
- BMI 18.5 to 28 kg/m2
- Able to give informed consent as documented by signature
Exclusion
- Concomitant medication other than prescription free analgesics (paracetamol and NSAID) and oral contraceptives
- Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus)
- Hyper- or hypothyroidism
- Smoker / habitual tobacco use
- Weight change of \>5% within 3 months prior to inclusion
- Hypersensitivity to cold (e.g. Raynaud syndrome)
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
- Enrolment of the investigator, his/her family members, employees and other dependent persons
- Enrolment into another study using ionizing radiation within the previous 12 months
- Enrolment into another study including a pharmacological or nutritional intervention
- Pregnancy or lactation
- Lab parameters
- Serum-Creatinine: above 1.5x upper limit of normal (ULN)
- Glycated Hemoglobin (HbA1c): above 6.0%
- Random plasma glucose \>11 mM
Key Trial Info
Start Date :
October 12 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 15 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06078345
Start Date
October 12 2023
End Date
August 15 2025
Last Update
November 25 2025
Active Locations (1)
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1
University Hospital Basel, Dept. of Endocrinology
Basel, Switzerland