Status:
NOT_YET_RECRUITING
Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Spasmodic Dysphonia Association
Conditions:
Presbylarynx
Aspiration
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders. This study will expand on the previous research t...
Detailed Description
PRIMARY OBJECTIVES: I. Laryngeal sensation as measured by elicitation of laryngeal adductor reflex (LAR). II. To compare the elicitation of laryngeal adductor reflex (LAR) threshold/probability to t...
Eligibility Criteria
Inclusion
- Age \<=18 years.
- Individuals without a laryngopharyngeal disorder (health controls) or with a laryngopharyngeal disorder. Laryngopharyngeal disorder includes but is not limited to: presbylarynx, aspiration; spasmodic dysphonia; globus pharynges; vocal fold paralysis; iatrogenic injury to the larynx; muscle tension dysphonia; neurogenic dysphagia; laryngeal sensory neuropathy; and laryngopharyngeal disorders resulting from prior radiation therapy in individuals with a history of head and neck cancer who have completed radiation therapy as primary or adjuvant cancer treatment
- Ability and willingness to comply with study procedures.
- Ability to understand a written informed consent document, and the willingness to sign it.
Exclusion
- Non-English speaking.
- Laryngopharyngeal structures are not accessible on exam.
- Known contraindication to any study-related procedure, or history of being unable to tolerate laryngoscopy.
- Vocal fold immobility or severe hypomobility on adduction.
- For head and neck cancer survivors only: Currently undergoing radiation therapy for head and neck cancer (i.e., primary/adjuvant radiation therapy treatment plan is not yet completed).
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06078527
Start Date
October 1 2025
End Date
January 31 2028
Last Update
July 23 2025
Active Locations (1)
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1
University of California, San Francisco
San Francisco, California, United States, 94143