Status:
COMPLETED
The Kallikrein-Kinin System in Cardiac Surgery
Lead Sponsor:
Qin Zhang
Conditions:
Cardiosurgery
Eligibility:
All Genders
18-80 years
Brief Summary
We aimed to established an interlink among the kallikrein-kinin system (KKS), endothelial dysfunction and cardiac inflammation in response to cardiosurgery , using clinic investigation.
Detailed Description
The KKS, which is located on the vascular endothelium, plays a pivotal role in maintaining cardiovascular homeostasis. Tissue kallikrein (TK), a serine protease and a key enzyme of the KKS, is respons...
Eligibility Criteria
Inclusion
- 1\) Willing to participate in the study. 2) Age ≥ 18 years and ≤ 80 years. 3) Patients undergoing cardiac surgery: (coronary artery bypass grafting, heart valve surgery, Morrow operation, aortic dissection surgery).
Exclusion
- 1\) Patients with heart failure. 2) Patients experiencing adverse events during surgery. 3) Solid organ or bone marrow transplant recipients. 4) Patients with autoimmune diseases, tumors, or those who received high-dose steroid or immunosuppressant therapy within the past two months. 5) Deemed unsuitable for participation in this study by the researchers' judgment.
- \-
Key Trial Info
Start Date :
September 20 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 30 2024
Estimated Enrollment :
308 Patients enrolled
Trial Details
Trial ID
NCT06080295
Start Date
September 20 2023
End Date
October 30 2024
Last Update
January 20 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030