Status:
COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
University of Copenhagen
Conditions:
Mitochondrial Myopathies
Mitochondrial Diseases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The overarching aim of this intervention study is to interrogate the interconnection between the muscle mitochondrial adaptations and the changes in muscle insulin sensitivity elicited by exercise tra...
Detailed Description
Background: Peripheral insulin resistance is a major risk factor for metabolic diseases such as type 2 diabetes. Skeletal muscle accounts for the majority of insulin-stimulated glucose disposal, hence...
Eligibility Criteria
Inclusion
- Known m.3243A\>G mutation in the MT-TL1 gene encoding the mitochondrial leucyl-tRNA 1 gene
- Other known mtDNA point mutations
Exclusion
- Use of antiarrhythmic medications or other medications which, in the opinion of the investigators, have the potential to affect outcome measures.
- Diagnosed severe heart disease, dysregulated thyroid gland conditions, or other dysregulated endocrinopathies, or other conditions which, in the opinion of the investigators, have the potential to affect outcome measures.
- Pregnancy
Key Trial Info
Start Date :
September 22 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 28 2025
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT06080594
Start Date
September 22 2024
End Date
February 28 2025
Last Update
June 22 2025
Active Locations (1)
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1
Rigshospitalet
Copenhagen, Denmark, Denmark, 2100