Status:
RECRUITING
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Lead Sponsor:
San Francisco Veterans Affairs Medical Center
Conditions:
Depression
Depressive Disorder
Eligibility:
All Genders
18-70 years
Brief Summary
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related informat...
Detailed Description
This study combines clinically motivated questions with in-depth study of neurobiological mechanisms to evaluate how reward system neurobiology contributes to expression of reward-related deficits, su...
Eligibility Criteria
Inclusion
- Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.
- Because this study includes an MRI, part of the screening process will be to ensure you don't have any metal in your body, you do not have head or neck tattoos, and you are comfortable inside the MRI scanner.
- 18-70 years with a diagnosis of major depressive disorder (MDD) for MDD group, or without for unaffected comparison (UC) group
- Negative metal screen for MRI safety
- Normal (or corrected to normal) vision
Exclusion
- Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms)
- Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms
- Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology)
- Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions
- Known claustrophobia
- Current Pregnancy
- IQ estimate \< 70
Key Trial Info
Start Date :
June 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06080646
Start Date
June 1 2021
End Date
September 1 2025
Last Update
August 2 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
San Francisco Healthcare System
San Francisco, California, United States, 94121