Status:
UNKNOWN
Evaluation of Muscle Oxidative Capacity Relationship With Muscular Endurance, Fatigue (Multiple Sclerosis).
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-80 years
Brief Summary
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. It is characterized by different progressive forms with periods of flare-ups interspersed with phases of remiss...
Detailed Description
Following an arterial occlusion, the rate of decay of the NIRS signal is only dependent on local O2 consumption. Following an exercise increasing the oxygen consumption of the muscle (isometric contra...
Eligibility Criteria
Inclusion
- Patients with Multiple Sclerosis (MS) with a diagnosis established by MRI.
- Patients with a Kurtzke Expanded Disability Status Scale (EDSS) score \< 5.
- Body mass index (BMI) \< 30 Kg/m².
- Thickness of subcutaneous adipose tissue at the calf ≤ 20 mm.
- MS patients without neurological signs of flare-up since 1 month.
- MS patients who have not had any treatment modification during the last 2 months.
- Subjects affiliated to French health care system (for France).
- Volunteers who have given their written consent.
Exclusion
- Patients suffering from progressive psychiatric pathologies (active psychosis, , etc.) or the presence of another serious unstabilized pathology (decompensated heart failure, progressive terminal cancer, etc.).
- People with poorly controlled or unstable cardiovascular disease.
- Major osteoarticular or neurological problems completely preventing the proper performance of the various tests.
- Persons under guardianship, curatorship, deprived of liberty or safeguarding justice.
- Pregnant or lactating women.
Key Trial Info
Start Date :
January 14 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06083194
Start Date
January 14 2024
End Date
June 1 2025
Last Update
January 17 2024
Active Locations (1)
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1
CHU clermont-ferrand
Clermont-Ferrand, France, 63000