Status:
UNKNOWN
68Ga-TCR-FAPI PET/CT in Patients With Various Types of Cancer
Lead Sponsor:
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Collaborating Sponsors:
Peking University
Peking University Cancer Hospital & Institute
Conditions:
Malignant Tumor
Positron Emission Tomography
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Adding targeted covalent radiopharmaceutical (TCR) moiety to fibroblast activation protein inhibitor (FAPI) can increase tumor uptake and tumor retention in pre-clinical studies. This study is an open...
Detailed Description
TCR-FAPI can covalently bind to FAP that increase tumor uptake and tumor retention in pre-clinical studies, which elevates the ability for cancer imaging and facilitates the targeted radionuclide ther...
Eligibility Criteria
Inclusion
- Suspected to have malignant tumors (supported by MRI and/or CT and/or tumor markers and/or pathology report), the tumor may be newly diagnosed or previously treated;
- Meet the indications for PET examination, show a clear indication and no contraindications;
- Have a performance status of score ≥ 80 on KPS scale or score 0-1 points on ECOG scale, a relatively good general situation;
- No major organ dysfunction (heart, lung, liver, kidney and other major organ include), acute or life-threatening status of infection;
- Be ≥ 18 years of age;
- Be willing and able to understand the research content and provide written informed consent/assent for the trial.
Exclusion
- Have a history of imaging agent allergies;
- Does not meet the PET-CT scan sedation requirements, or has contraindications for PET-CT examination;
- Be pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial.
Key Trial Info
Start Date :
May 5 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06084767
Start Date
May 5 2023
End Date
December 30 2025
Last Update
October 23 2023
Active Locations (1)
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1
Peking University Cancer Hospital
Beijing, China