Status:
ACTIVE_NOT_RECRUITING
Circulating Tumor DNA Sequencing in Patients With Peripheral T-cell Lymphomas
Lead Sponsor:
Centre Henri Becquerel
Conditions:
Peripheral T Cell Lymphoma
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to assess the feasibility of analyzing circulating tumor DNA (ctDNA) as a biomarker using the shallow whole genome sequencing (lpWGS) technique coupled with deep sequencin...
Detailed Description
Peripheral T-cell lymphomas (PTCL) are a rare and heterogeneous group of diseases resulting from the clonal proliferation of mature post-thymic lymphocytes. These T-cell neoplasms account for approxim...
Eligibility Criteria
Inclusion
- Aged 18 or over
- Newly diagnosed or relapsed/refractory peripheral T-cell lymphoma (PTCL), including T/NK lymphoma (NKTL)
- Pre-therapeutic FDG PET-CT already performed
- Signed informed consent
- Patients affiliated with or beneficiaries of a health insurance plan
Exclusion
- Cutaneous T-cell lymphomas without systemic involvement
- Pregnant or breastfeeding women
- For newly diagnosed patients: patient who has already started the first systemic treatment for their lymphoma (apart from pre-phase corticosteroid therapy which is authorized)
- For patients in a relapsed/refractory situation: Patient who has already started the new specific line of lymphoma treatment planned for the current relapsed/refractory situation (apart from pre-phase corticosteroid therapy which is authorized)
- Lack of patient consent
- Patient whose weight is less than 30 kg
- Protected adult or deprived of freedoms (under guardianship or curatorship)
- Patient unable to understand the study for any reason or to comply with the constraints of the trial (language, psychological, geographic problem, etc.).
Key Trial Info
Start Date :
January 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 4 2026
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06089941
Start Date
January 1 2024
End Date
November 4 2026
Last Update
January 2 2026
Active Locations (1)
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1
Centre Henri Becquerel
Rouen, France