Status:
RECRUITING
ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells
Lead Sponsor:
UNC Lineberger Comprehensive Cancer Center
Conditions:
Hodgkin Lymphoma
Relapse
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
Despite the progress in the therapy, Hodgkin's Lymphoma (HL) remains fatal for more than 15% of patients. Even in patients who are cured, the morbidity of therapy is substantial and long-lasting. New ...
Eligibility Criteria
Inclusion
- During the period of cell procurement and lymphodepletion, subjects will be eligible to receive standard-of-care therapy e.g., chemotherapy or radiation therapy to stabilize their disease if the treating physician feels it is in the subject's best interests. Eligibility must be maintained up until the subject is procured, receives lymphodepletion, or receives treatment for the subject to be considered eligible to proceed with the specific phase of the study.
- Unless otherwise noted, subjects must meet all of the following criteria to participate in all phases of the study. As these criteria are unchanging they will be evaluated at the time of initial enrollment and not continuously throughout the study.
- Written informed consent and HIPAA authorization for release of personal health information explained to, understood by, and signed by the subject or legally authorized representative.
- Age ≥ 18 years at the time of consent.
- Karnofsky score of \> 60%
- The subject must have a diagnosis of Classical Hodgkin Lymphoma according to World Health Organization criteria.
Exclusion
- Subjects had major surgery within 28 days.
- Subject received investigational agents or tumor vaccines within 3 weeks.
- Subject received chemotherapy or radiation therapy within the previous 3 weeks.
Key Trial Info
Start Date :
April 25 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2031
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT06090864
Start Date
April 25 2024
End Date
July 1 2031
Last Update
October 20 2025
Active Locations (1)
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1
Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599