Status:
COMPLETED
STN-DBS and the Risk of Sialorrhea
Lead Sponsor:
Qilu Hospital of Shandong University
Conditions:
Parkinson Disease
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
OBJECTIVE: The aims of this study were to assess the incidence rate and risk factors for sialorrhea in the long-term follow-up in a cohort of 170 patients with advanced Parkinson's disease \[84 with d...
Detailed Description
IMPORTANCE: Sialorrhea is a frequent and disabling symptom in patients with PD. No prospective study has been specifically designed to test the effects of DBS on sialorrhea development. OBJECTIVE: Th...
Eligibility Criteria
Inclusion
- Clinical diagnosis of Alzheimer's Disease
- Age between 20 and 80 years
- without drooling
- swallowing function \<5 on the Drooling Rate Scale (DRS).
- Medications affecting drooling had to have stopped medications at least 4 weeks before study entry.
Exclusion
- Not he typical PD
- Subjects on warfarin,
- with significant medical illnesses or neuromuscular transmission disorders
- past use of BoNT
- -cognitive impairment (\<23/30 on Mini Mental Status Exam) were excluded.
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2023
Estimated Enrollment :
234 Patients enrolled
Trial Details
Trial ID
NCT06090929
Start Date
January 1 2019
End Date
June 1 2023
Last Update
October 19 2023
Active Locations (1)
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1
Chao Zhang
Jinan, Shandong, China, 250100