Status:
RECRUITING
Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy
Lead Sponsor:
Beni-Suef University
Conditions:
Neuropathy in Cacer Patien
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
This study aimed to elucidate the relationship between the Efficacy and Safety of Comparison of the Efficacy and Safety Duloxetine augmented with gabapentin and amitriptyline augmented with Duloxetine...
Eligibility Criteria
Inclusion
- -Patients of any age must have histologically or cytologically confirmed cancer by the Laboratory of Pathology.
- Patients must sign an informed consent form (ICF) voluntarily and be able to understand and comply with the requirements of the study;
- Patients must be 18 to 75 years of age (including cut-offs) on the date of signing the informed consent form, regardless of gender;
- Patients must received treatment with a chemotherapy regimen .
- Patients must have ≥ grade 1 sensory chemotherapy-induced peripheral neuropathy (CIPN) with NRS ≥ 4/10 according to the NCI Common Toxicity Criteria for Adverse Events (CTCAE) v.5.0 grading scale
- Eastern Cooperative Oncology Group performance status (ECOG PS): 0-2;
- Expected survival of ≥ 3 months
- There is no maximum number of prior medical therapies.
Exclusion
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to duloxetine, amitriptyline and gabapentin
- Pregnant women are excluded from this study.
- Life expectancy less than 6 months
- Inability or unwillingness to comply with research protocols.
- Patients with the presence of active brain or meningeal metastases.
- Patients with the presence of uncontrolled closed-angle glaucoma.
- Patients with the presence of neuropathy caused by any type of nerve compression as diabetes.
- The presence of mental illness, epilepsy, mania, suicidal depression, dementia or alcohol or drug abuse that may have an impact on compliance with trial requirements.
- The presence of comorbid cardiovascular disease, including but not limited to: (1) New York Heart Association (NYHA) criteria ≥ grade 2 heart failure; (2) severe/unstable angina pectoris; (3) myocardial infarction or cerebrovascular accident within 6 months prior to first dose; (4) atrial fibrillation and supraventricular or ventricular arrhythmias requiring treatment; (5) pre-existing symptomatic superior vena cava syndrome; (6) corrected QT interval (QTc) \> 450 ms (men); QTc \> 470 ms (women); (7) hypertensive disease not controlled by antihypertensive medication: systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg;
- Patients with other medical history or evidence of disease that has the potential to confound trial results are excluded from the study,
Key Trial Info
Start Date :
October 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT06091553
Start Date
October 10 2023
End Date
December 31 2024
Last Update
April 16 2024
Active Locations (1)
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1
Beni-Seuf University Hospital
Banī Suwayf, Egypt