Status:
RECRUITING
tACS to Enhance Language Abilities
Lead Sponsor:
University of Pennsylvania
Conditions:
Stroke
Aphasia, Acquired
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and...
Detailed Description
This research will investigate whether transcranial alternating current stimulation (tACS), a form of noninvasive brain stimulation, can be used to enhance language abilities in people with aphasia (P...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Persons with Aphasia:
- Presence of aphasia
- Suffered a single, left hemisphere stroke
- Stroke ≥6 months old (chronic) at the time of enrollment
- Inclusion Criteria for Healthy Controls:
- Right-handedness
- Must be able to understand the nature of the study, and give informed consent
- Exclusion criteria for Persons with Aphasia:
- Inability to understand the nature of the study
- Marked naming impairment
- Impaired non-verbal, conceptual processing
- History of significant medical or neurological disorder (other than stroke)
- History of significant or poorly controlled psychiatric disorders
- Current abuse of alcohol or drugs, prescription or otherwise
- Nursing a child, pregnancy, or intent to become pregnant during the study
- Clinically significant hearing loss
- Contraindications to tACS
- Contraindications to MRI
- Exclusion Criteria for Healthy Controls
- Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint
- Any unrelated neurologic or physical condition that impairs communication ability
- History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit
- Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations
- A medically unstable cardiopulmonary or metabolic disorder
- Terminal illness associated with survival \<12 months
- Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician
- Current abuse of alcohol or drugs, prescription or otherwise
- Contraindications to tACS
- Contraindications to MRI
Exclusion
Key Trial Info
Start Date :
July 12 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2028
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06092814
Start Date
July 12 2024
End Date
August 31 2028
Last Update
August 8 2025
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104