Status:
RECRUITING
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Lead Sponsor:
University of Delaware
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Salt-Sensitivity of Blood Pressure
Eligibility:
All Genders
40-60 years
Phase:
PHASE4
Brief Summary
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain res...
Detailed Description
The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans ...
Eligibility Criteria
Inclusion
- Age: \> 40 years or \< 60 years
- Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg
- BMI: \> 18.5 kg/m2 or \< 30 kg/m2
- Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L
- No history of cardiovascular, renal, metabolic, or neurological disease
Exclusion
- Age: \< 40 years or \> 60 years
- Blood pressure: \< 100/60 mmHg or \> 140/90 mmHg
- BMI: \< 18.5 kg/m2 or \> 30 kg/m2
- Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L
- Abnormal ECG
- History of - cardiovascular, cancer, metabolic, respiratory, renal disease
- Hormone replacement therapy
- Current tobacco or nicotine use
- Pregnant or nursing mothers
- Major brain injury (concussions do not count)
- Clinically diagnosed psychiatric or neurological disorder
- Clinically diagnosed anxiety or depression
- Psychiatric, neurological, anxiety or depression medications
- Hypertension medications
- Sulfonamide drug allergy
- Contra-indications to MRI (implants, metal, etc)
- Claustrophobia
Key Trial Info
Start Date :
March 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2028
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06094816
Start Date
March 5 2024
End Date
July 1 2028
Last Update
December 11 2025
Active Locations (1)
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1
University of Delaware
Newark, Delaware, United States, 19713